coagulation function analyzer cp-2000 Search Results


cp2004.sas  (SAS institute)
90
SAS institute cp2004.sas
Cp2004.Sas, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/pm15641426-311-58-61?v=SAS+institute
Average 90 stars, based on 1 article reviews
cp2004.sas - by Bioz Stars, 2026-08
90/100 stars
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cell pharm (cp) 2000 hollow fiber bioreactor  (Biovest Inc)
90
Biovest Inc cell pharm (cp) 2000 hollow fiber bioreactor
Cell Pharm (Cp) 2000 Hollow Fiber Bioreactor, supplied by Biovest Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/us07776330-317-9-23?v=Biovest+Inc
Average 90 stars, based on 1 article reviews
cell pharm (cp) 2000 hollow fiber bioreactor - by Bioz Stars, 2026-08
90/100 stars
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automated coagulation analyzer coapresta 2000  (SEKISUI MEDICAL)
90
SEKISUI MEDICAL automated coagulation analyzer coapresta 2000
Automated Coagulation Analyzer Coapresta 2000, supplied by SEKISUI MEDICAL, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/pm30221460-3524-6-11?v=SEKISUI+MEDICAL
Average 90 stars, based on 1 article reviews
automated coagulation analyzer coapresta 2000 - by Bioz Stars, 2026-08
90/100 stars
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digitalized film recorder  (Mitsubishi Electric Corporation)
86
Mitsubishi Electric Corporation digitalized film recorder
Digitalized Film Recorder, supplied by Mitsubishi Electric Corporation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/pm11891186-88-7-23?v=Mitsubishi+Electric+Corporation
Average 86 stars, based on 1 article reviews
digitalized film recorder - by Bioz Stars, 2026-08
86/100 stars
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gc micro gc cp2002  (GL Sciences)
90
GL Sciences gc micro gc cp2002
Gc Micro Gc Cp2002, supplied by GL Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/pm15280275-44-10-13?v=GL+Sciences
Average 90 stars, based on 1 article reviews
gc micro gc cp2002 - by Bioz Stars, 2026-08
90/100 stars
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varian micro gc  (Varian Medical)
86
Varian Medical varian micro gc
Varian Micro Gc, supplied by Varian Medical, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1021_slash_cm202105k____cm202105k_si_001-15-8-8?v=Varian+Medical
Average 86 stars, based on 1 article reviews
varian micro gc - by Bioz Stars, 2026-08
86/100 stars
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cne cp2010  (Jinzhou Jiutai Pharmaceutical Co Ltd)
90
Jinzhou Jiutai Pharmaceutical Co Ltd cne cp2010
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
Cne Cp2010, supplied by Jinzhou Jiutai Pharmaceutical Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/pmc04296965-38-7-8?v=Jinzhou+Jiutai+Pharmaceutical+Co+Ltd
Average 90 stars, based on 1 article reviews
cne cp2010 - by Bioz Stars, 2026-08
90/100 stars
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cp200 133 g/mm spectrograph  (HORIBA Ltd)
90
HORIBA Ltd cp200 133 g/mm spectrograph
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
Cp200 133 G/Mm Spectrograph, supplied by HORIBA Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1016_slash_j__profoo__2011__09__080-43-26-30?v=HORIBA+Ltd
Average 90 stars, based on 1 article reviews
cp200 133 g/mm spectrograph - by Bioz Stars, 2026-08
90/100 stars
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gas microchromatograph micro-gc cp2002  (Chrompack International BV)
90
Chrompack International BV gas microchromatograph micro-gc cp2002
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
Gas Microchromatograph Micro Gc Cp2002, supplied by Chrompack International BV, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1627_slash_jpi__47__225-93-6-9?v=Chrompack+International+BV
Average 90 stars, based on 1 article reviews
gas microchromatograph micro-gc cp2002 - by Bioz Stars, 2026-08
90/100 stars
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electronic balance cp2002  (OHAUS Corporation)
90
OHAUS Corporation electronic balance cp2002
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
Electronic Balance Cp2002, supplied by OHAUS Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1016_slash_j__memsci__2015__01__036-83-2-4?v=OHAUS+Corporation
Average 90 stars, based on 1 article reviews
electronic balance cp2002 - by Bioz Stars, 2026-08
90/100 stars
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thermostat  (JULABO GmbH)
94
JULABO GmbH thermostat
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
Thermostat, supplied by JULABO GmbH, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1016_slash_j__seppur__2024__128351-170-9-13?v=JULABO+GmbH
Average 94 stars, based on 1 article reviews
thermostat - by Bioz Stars, 2026-08
94/100 stars
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c-port device  (Dextera Inc)
90
Dextera Inc c-port device
Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of <t>CNE</t> and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, <t>blank</t> <t>nanoemulsion;</t> BHI, Brain heart infusion; PBS, phosphate buffered saline.
C Port Device, supplied by Dextera Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/coagulation+function+analyzer+cp-2000/10__1097_slash_imi__0000000000000533-26-21-15?v=Dextera+Inc
Average 90 stars, based on 1 article reviews
c-port device - by Bioz Stars, 2026-08
90/100 stars
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Image Search Results


Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of CNE and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, blank nanoemulsion; BHI, Brain heart infusion; PBS, phosphate buffered saline.

Journal: International Journal of Nanomedicine

Article Title: Inhibited biofilm formation and improved antibacterial activity of a novel nanoemulsion against cariogenic Streptococcus mutans in vitro and in vivo

doi: 10.2147/IJN.S72920

Figure Lengend Snippet: Results of release profile and antibacterial activity against Streptococcus mutans in vitro: ( A ) In vitro release profile of CNE and free CHX suspension in PBS as release medium; ( B ) In vitro release profile of CNE and free CHX suspension in artificial saliva as release medium; ( C ) Results of the minimum inhibitory concentrations (MIC) study; ( D ) 24-well plate figure of MIC; ( E ) BHI agar plate of minimum bactericidal concentrations (MBC); ( F ) Results of the time-kill assay. Note: A black straight line was marked the almost release ( A , B ). We observed that all S. mutans bacteria were killed under the 0.05 absorbance value for the optical density (red line) at 595 nm ( A , B ). The visibly clear groups of the 24-well plate were marked by red squares ( D ). Growing white bacterial colonies are indicated with a red circle ( E ). 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference ( A – C , F ). Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; CFU, colony forming unit; BNE, blank nanoemulsion; BHI, Brain heart infusion; PBS, phosphate buffered saline.

Article Snippet: The nanoemulsion composition was screened based on CNE (Jinzhou Jiutai Pharmaceutical Co., Ltd, Liaoning, People’s Republic of China; CP2010, 98.3%) solubility in five types of oil phases (ie, IPM [isopropyl myristate; Croda, Goole, UK], GTCC [caprylic/capric triglyceride; Beijing Fengli Pharmaceutical Co., Ltd, Beijing, People’s Republic of China], liquid paraffin, peanut oil, and soybean oil), five types of cosurfactants (ie, ethyl, propylene glycol, glycerin, Span 80, Span 85), and five types of surfactants (ie, Tween 80, Tween 85, Tween 20, RH 40 [Cremophor RH 40; BASF, Mumbai, India], and EL 40 [Cremophor EL 40; BASF, Mumbai, India]).

Techniques: Activity Assay, In Vitro, Suspension, Time-Kill Assay, Bacteria, Control, Saline

Antibacterial activity and dental score results against Streptococcus mutans in vivo: ( A ) Oral S. mutans colony-forming unit results; ( B ) Dental score results for enamel only; ( C ) Dental score results for slight dentinal lesions (Ds); ( D ) Dental score results for moderate dentinal lesions (Dm). Note: 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solutionl; BNE, blank nanoemulsion.

Journal: International Journal of Nanomedicine

Article Title: Inhibited biofilm formation and improved antibacterial activity of a novel nanoemulsion against cariogenic Streptococcus mutans in vitro and in vivo

doi: 10.2147/IJN.S72920

Figure Lengend Snippet: Antibacterial activity and dental score results against Streptococcus mutans in vivo: ( A ) Oral S. mutans colony-forming unit results; ( B ) Dental score results for enamel only; ( C ) Dental score results for slight dentinal lesions (Ds); ( D ) Dental score results for moderate dentinal lesions (Dm). Note: 700610 means S. mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solutionl; BNE, blank nanoemulsion.

Article Snippet: The nanoemulsion composition was screened based on CNE (Jinzhou Jiutai Pharmaceutical Co., Ltd, Liaoning, People’s Republic of China; CP2010, 98.3%) solubility in five types of oil phases (ie, IPM [isopropyl myristate; Croda, Goole, UK], GTCC [caprylic/capric triglyceride; Beijing Fengli Pharmaceutical Co., Ltd, Beijing, People’s Republic of China], liquid paraffin, peanut oil, and soybean oil), five types of cosurfactants (ie, ethyl, propylene glycol, glycerin, Span 80, Span 85), and five types of surfactants (ie, Tween 80, Tween 85, Tween 20, RH 40 [Cremophor RH 40; BASF, Mumbai, India], and EL 40 [Cremophor EL 40; BASF, Mumbai, India]).

Techniques: Activity Assay, In Vivo, Control

Photos of teeth with dental caries: treated with a 2 mg/mL CHX water solution ( A ); treated with a 5 mg/mL CHX water suspension ( B ); treated with 2 mg/mL CNE ( C ); treated with 5 mg/mL CNE ( D ); treated with BNE ( E ); 700610 control ( F ). Note: 700610 means Streptococcus mutans control. These photos were taken using a stereo microscope at the original magnification (10×23 times). Green arrows indicate enamel only dental lesions; the blue arrows indicate slight dentinal lesions; the red arrows indicate moderate dentinal lesions. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Journal: International Journal of Nanomedicine

Article Title: Inhibited biofilm formation and improved antibacterial activity of a novel nanoemulsion against cariogenic Streptococcus mutans in vitro and in vivo

doi: 10.2147/IJN.S72920

Figure Lengend Snippet: Photos of teeth with dental caries: treated with a 2 mg/mL CHX water solution ( A ); treated with a 5 mg/mL CHX water suspension ( B ); treated with 2 mg/mL CNE ( C ); treated with 5 mg/mL CNE ( D ); treated with BNE ( E ); 700610 control ( F ). Note: 700610 means Streptococcus mutans control. These photos were taken using a stereo microscope at the original magnification (10×23 times). Green arrows indicate enamel only dental lesions; the blue arrows indicate slight dentinal lesions; the red arrows indicate moderate dentinal lesions. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Article Snippet: The nanoemulsion composition was screened based on CNE (Jinzhou Jiutai Pharmaceutical Co., Ltd, Liaoning, People’s Republic of China; CP2010, 98.3%) solubility in five types of oil phases (ie, IPM [isopropyl myristate; Croda, Goole, UK], GTCC [caprylic/capric triglyceride; Beijing Fengli Pharmaceutical Co., Ltd, Beijing, People’s Republic of China], liquid paraffin, peanut oil, and soybean oil), five types of cosurfactants (ie, ethyl, propylene glycol, glycerin, Span 80, Span 85), and five types of surfactants (ie, Tween 80, Tween 85, Tween 20, RH 40 [Cremophor RH 40; BASF, Mumbai, India], and EL 40 [Cremophor EL 40; BASF, Mumbai, India]).

Techniques: Suspension, Control, Microscopy

Inhibition of biofilm formation and biofilm surface structure figure: biofilm formation inhibition results for CNE ( A ); biofilm surface structure after CNE treatment (×2,000 times) ( B ); biofilm surface structure after CHX treatment (×2,000 times) ( C ); Biofilm surface structure after CNE treatment (×6,000 times) ( D ); Biofilm surface structure after CHX treatment (×6,000 times) ( E ). Notes: 700610 means Streptococcus mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Journal: International Journal of Nanomedicine

Article Title: Inhibited biofilm formation and improved antibacterial activity of a novel nanoemulsion against cariogenic Streptococcus mutans in vitro and in vivo

doi: 10.2147/IJN.S72920

Figure Lengend Snippet: Inhibition of biofilm formation and biofilm surface structure figure: biofilm formation inhibition results for CNE ( A ); biofilm surface structure after CNE treatment (×2,000 times) ( B ); biofilm surface structure after CHX treatment (×2,000 times) ( C ); Biofilm surface structure after CNE treatment (×6,000 times) ( D ); Biofilm surface structure after CHX treatment (×6,000 times) ( E ). Notes: 700610 means Streptococcus mutans control. ** P <0.01 represent a significant difference; * P <0.05 represent a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Article Snippet: The nanoemulsion composition was screened based on CNE (Jinzhou Jiutai Pharmaceutical Co., Ltd, Liaoning, People’s Republic of China; CP2010, 98.3%) solubility in five types of oil phases (ie, IPM [isopropyl myristate; Croda, Goole, UK], GTCC [caprylic/capric triglyceride; Beijing Fengli Pharmaceutical Co., Ltd, Beijing, People’s Republic of China], liquid paraffin, peanut oil, and soybean oil), five types of cosurfactants (ie, ethyl, propylene glycol, glycerin, Span 80, Span 85), and five types of surfactants (ie, Tween 80, Tween 85, Tween 20, RH 40 [Cremophor RH 40; BASF, Mumbai, India], and EL 40 [Cremophor EL 40; BASF, Mumbai, India]).

Techniques: Inhibition, Control

Cell membrane structural damage and cell membrane integrity results; ( A ) cell membrane structural damage after treatment with 0.2 μg/mL CNE (×39,000 times); ( B ) cell membrane structural damage after treatment with 0.2 μg/mL CHX (×39,000 times); ( C ) cell membrane structural damage after treatment with 0.2 μg/mL CNE (×93,000 times); ( D ) cell membrane structural damage after treatment with 0.2 μg/mL CHX (×93,000 times); ( E ) leaking DNA concentration of Streptococcus mutans treated CNE; ( F ) leaking protein concentration of S. mutans treated CNE. Notes: Cell membrane structural damage was remarked with red and arrowed circle. 700610 means S. mutans control. ** P <0.01 represents a significant difference; * P <0.05 represents a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Journal: International Journal of Nanomedicine

Article Title: Inhibited biofilm formation and improved antibacterial activity of a novel nanoemulsion against cariogenic Streptococcus mutans in vitro and in vivo

doi: 10.2147/IJN.S72920

Figure Lengend Snippet: Cell membrane structural damage and cell membrane integrity results; ( A ) cell membrane structural damage after treatment with 0.2 μg/mL CNE (×39,000 times); ( B ) cell membrane structural damage after treatment with 0.2 μg/mL CHX (×39,000 times); ( C ) cell membrane structural damage after treatment with 0.2 μg/mL CNE (×93,000 times); ( D ) cell membrane structural damage after treatment with 0.2 μg/mL CHX (×93,000 times); ( E ) leaking DNA concentration of Streptococcus mutans treated CNE; ( F ) leaking protein concentration of S. mutans treated CNE. Notes: Cell membrane structural damage was remarked with red and arrowed circle. 700610 means S. mutans control. ** P <0.01 represents a significant difference; * P <0.05 represents a difference. Abbreviations: CNE, chlorhexidine acetate; CHX, chlorhexidine acetate water solution; BNE, blank nanoemulsion.

Article Snippet: The nanoemulsion composition was screened based on CNE (Jinzhou Jiutai Pharmaceutical Co., Ltd, Liaoning, People’s Republic of China; CP2010, 98.3%) solubility in five types of oil phases (ie, IPM [isopropyl myristate; Croda, Goole, UK], GTCC [caprylic/capric triglyceride; Beijing Fengli Pharmaceutical Co., Ltd, Beijing, People’s Republic of China], liquid paraffin, peanut oil, and soybean oil), five types of cosurfactants (ie, ethyl, propylene glycol, glycerin, Span 80, Span 85), and five types of surfactants (ie, Tween 80, Tween 85, Tween 20, RH 40 [Cremophor RH 40; BASF, Mumbai, India], and EL 40 [Cremophor EL 40; BASF, Mumbai, India]).

Techniques: Membrane, Concentration Assay, Protein Concentration, Control